Genetic variants in transcription factors are associated with the pharmacokinetics and pharmacodynamics of metformin.

Goswami S, Yee SW, Stocker S, Mosley JD, Kubo M, Castro R, Mefford JA, Wen C, Liang X, Witte J, Brett C, Maeda S, Simpson MD, Hedderson MM, Davis RL, Roden DM, Giacomini KM, Savic RM
Clin Pharmacol Ther. 2014 96 (3): 370-9

PMID: 24853734 · PMCID: PMC4171106 · DOI:10.1038/clpt.2014.109

MeSH Terms (27)

Adult Aged Aged, 80 and over Biomarkers Diabetes Mellitus, Type 2 Female Genome-Wide Association Study Glycated Hemoglobin A Hepatocyte Nuclear Factor 4 Homozygote Humans Hypoglycemic Agents Male Metformin Middle Aged Models, Biological Multivariate Analysis Pharmacogenetics Phenotype Polymorphism, Single Nucleotide PPAR alpha Retrospective Studies Sp1 Transcription Factor Transcription Factors Treatment Outcome United States Young Adult

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