Inducible loss of one Apc allele in Lrig1-expressing progenitor cells results in multiple distal colonic tumors with features of familial adenomatous polyposis.

Powell AE, Vlacich G, Zhao ZY, McKinley ET, Washington MK, Manning HC, Coffey RJ
Am J Physiol Gastrointest Liver Physiol. 2014 307 (1): G16-23

PMID: 24833705 · PMCID: PMC4080164 · DOI:10.1152/ajpgi.00358.2013

MeSH Terms (17)

Adenomatous Polyposis Coli Animals Cell Transformation, Neoplastic Colon Colonoscopy Disease Models, Animal Genes, APC Hypertrophy Membrane Glycoproteins Mice Mice, Transgenic Neoplastic Stem Cells Nerve Tissue Proteins Positron-Emission Tomography Precancerous Conditions Retinal Pigment Epithelium Time Factors

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