Neurosensory perception of environmental cues modulates sperm motility critical for fertilization.

McKnight K, Hoang HD, Prasain JK, Brown N, Vibbert J, Hollister KA, Moore R, Ragains JR, Reese J, Miller MA
Science. 2014 344 (6185): 754-7

PMID: 24833393 · PMCID: PMC4094289 · DOI:10.1126/science.1250598

Environmental exposures affect gamete function and fertility, but the mechanisms are poorly understood. Here, we show that pheromones sensed by ciliated neurons in the Caenorhabditis elegans nose alter the lipid microenvironment within the oviduct, thereby affecting sperm motility. In favorable environments, pheromone-responsive sensory neurons secrete a transforming growth factor-β ligand called DAF-7, which acts as a neuroendocrine factor that stimulates prostaglandin-endoperoxide synthase [cyclooxygenase (Cox)]-independent prostaglandin synthesis in the ovary. Oocytes secrete F-class prostaglandins that guide sperm toward them. These prostaglandins are also synthesized in Cox knockout mice, raising the possibility that similar mechanisms exist in other animals. Our data indicate that environmental cues perceived by the female nervous system affect sperm function.

Copyright © 2014, American Association for the Advancement of Science.

MeSH Terms (18)

Animals Caenorhabditis elegans Caenorhabditis elegans Proteins Environmental Exposure Female Fertilization Male Neurons, Afferent Neurosecretory Systems Oocytes Ovum Perception Pheromones Prostaglandin-Endoperoxide Synthases Prostaglandins Spermatozoa Sperm Motility Transforming Growth Factor beta

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