Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs.

Mutisya D, Selvam C, Lunstad BD, Pallan PS, Haas A, Leake D, Egli M, Rozners E
Nucleic Acids Res. 2014 42 (10): 6542-51

PMID: 24813446 · PMCID: PMC4041415 · DOI:10.1093/nar/gku235

MeSH Terms (8)

Amides HeLa Cells Humans Models, Molecular Nucleic Acid Conformation Phosphates RNA, Small Interfering RNA Interference

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