Genetic variants of Adam17 differentially regulate TGFβ signaling to modify vascular pathology in mice and humans.

Kawasaki K, Freimuth J, Meyer DS, Lee MM, Tochimoto-Okamoto A, Benzinou M, Clermont FF, Wu G, Roy R, Letteboer TG, Ploos van Amstel JK, Giraud S, Dupuis-Girod S, Lesca G, Westermann CJ, Coffey RJ, Akhurst RJ
Proc Natl Acad Sci U S A. 2014 111 (21): 7723-8

PMID: 24812125 · PMCID: PMC4040598 · DOI:10.1073/pnas.1318761111

MeSH Terms (16)

ADAM17 Protein ADAM Proteins Animals Blood Vessels Gene Expression Regulation Genetic Variation Humans Immunohistochemistry Luciferases Mice Mice, Inbred C57BL NIH 3T3 Cells Signal Transduction Smad2 Protein Transforming Growth Factor beta Transforming Growth Factor beta1

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