Radiation Dosimetry of (18)F-FPEB in Humans.

Kessler RM, Seibyl J, Cowan RL, Zald D, Young JS, Ansari MS, Stabin MG
J Nucl Med. 2014 55 (7): 1119-21

PMID: 24799618 · DOI:10.2967/jnumed.113.133843

UNLABELLED - (18)F-3-fluoro-5-[(pyridin-3-yl)ethynyl]benzonitrile ((18)F-FPEB) is a potent and specific radioligand for the metabotropic glutamate receptor subtype 5 (mGluR5). Before undertaking clinical research studies with (18)F-FPEB, we performed studies of human radiation dosimetry.

METHODS - Serial whole-body scans were obtained in 9 healthy human subjects (5 men, 4 women) for 190-440 min after the intravenous administration of (18)F-FPEB. Radiation doses were estimated using the OLINDA/EXM software.

RESULTS - Peak organ doses were to the urinary bladder wall, 0.258 mGy/MBq (0.955 rad/mCi), and gallbladder wall, 0.193 mGy/MBq (0.716 rad/mCi). The effective dose was 0.025 mSv/MBq (0.0922 rem/mCi). The doses to the red marrow and spleen were 0.00797 mGy/MBq (0.0295 rad/mCi) and 0.00709 mGy/MBq (0.0262 rad/mCi), respectively. Reducing the urinary voiding interval to 60 or 90 min lowered the urinary bladder wall dose to 0.0885 mGy/MBq (0.327 rad/mCi) or 0.128 mGy/MBq (0.473 rad/mCi), respectively, and the effective dose to 0.0149 mSv/MBq (0.0551 rem/mCi) or 0.0171 mSv/MBq (0.0634 rem/mCi), respectively.

CONCLUSION - Urinary voiding should be performed during (18)F-FPEB studies to minimize radiation exposure to research subjects.

© 2014 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

MeSH Terms (13)

Adolescent Adult Female Humans Male Middle Aged Nitriles Positron-Emission Tomography Pyridines Radiometry Receptor, Metabotropic Glutamate 5 Whole Body Imaging Young Adult

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