A novel class of succinimide-derived negative allosteric modulators of metabotropic glutamate receptor subtype 1 provides insight into a disconnect in activity between the rat and human receptors.

Cho HP, Engers DW, Venable DF, Niswender CM, Lindsley CW, Conn PJ, Emmitte KA, Rodriguez AL
ACS Chem Neurosci. 2014 5 (7): 597-610

PMID: 24798819 · PMCID: PMC4102972 · DOI:10.1021/cn5000343

MeSH Terms (18)

Amino Acid Sequence Animals Calcium Cell Line CHO Cells Cricetulus Drug Evaluation, Preclinical Excitatory Amino Acid Agents Fluorescence HEK293 Cells High-Throughput Screening Assays Humans Mutation Rats Receptors, Metabotropic Glutamate Species Specificity Succinimides Transfection

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