Progress toward advanced understanding of metabotropic glutamate receptors: structure, signaling and therapeutic indications.

Yin S, Niswender CM
Cell Signal. 2014 26 (10): 2284-97

PMID: 24793301 · PMCID: PMC4130774 · DOI:10.1016/j.cellsig.2014.04.022

The metabotropic glutamate (mGlu) receptors are a group of Class C seven-transmembrane spanning/G protein-coupled receptors (7TMRs/GPCRs). These receptors are activated by glutamate, one of the standard amino acids and the major excitatory neurotransmitter. By activating G protein-dependent and non-G protein-dependent signaling pathways, mGlus modulate glutamatergic transmission both in the periphery and throughout the central nervous system. Since the discovery of the first mGlu receptor, and especially during the last decade, a great deal of progress has been made in understanding the signaling, structure, pharmacological manipulation and therapeutic indications of the 8 mGlu members.

Copyright © 2014 Elsevier Inc. All rights reserved.

MeSH Terms (8)

Allosteric Regulation Antipsychotic Agents Central Nervous System Diseases Humans Ligands Receptors, G-Protein-Coupled Receptors, Metabotropic Glutamate Signal Transduction

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