One-carbon metabolism dietary factors and distal gastric cancer risk in chinese women.

Kweon SS, Shu XO, Xiang Y, Yang G, Ji BT, Li H, Gao YT, Zheng W, Shrubsole MJ
Cancer Epidemiol Biomarkers Prev. 2014 23 (7): 1374-82

PMID: 24789845 · PMCID: PMC4082459 · DOI:10.1158/1055-9965.EPI-14-0038

BACKGROUND - Previous studies on the association between one-carbon dietary factors and gastric cancer risk have been inconsistent.

METHODS - We investigated this association using data from a prospective study, the Shanghai Women's Health Study (1997-2010), including 323 distal gastric cancer cases identified from 73,009 Chinese women. HRs and 95% confidence intervals (CI) were estimated using Cox proportional hazard regression after adjusting for confounders.

RESULTS - Overall, no statistically significant association of gastric cancer was observed with dietary intake of folate, methionine, or B vitamins. However, when stratified by menopausal status, higher intake of riboflavin was associated with decreased gastric cancer risk in premenopausal women with HR of 0.35 (95% CI, 0.17-0.73), 0.48 (0.24-0.97), 0.28 (0.12-0.65), and 0.23 (0.07-0.91), respectively, for the quintiles 2 to 5 intake groups compared with the lowest quintile intake (P for trend = 0.02). Among premenopausal women, highest intake of folate was associated with increased gastric cancer risk (HR, 2.62; 95% CI, 1.04-6.59). There were no statistically significant associations observed among postmenopausal women.

CONCLUSIONS - These results suggest that dietary factors involved in one-carbon metabolism are associated with gastric cancer risk among premenopausal women.

IMPACT - Riboflavin may be a protective factor and folate may be a risk factor for premenopausal gastric cancer.

©2014 American Association for Cancer Research.

MeSH Terms (12)

Adult Aged Asian Continental Ancestry Group Diet Diet Surveys Female Folic Acid Humans Methionine Middle Aged Stomach Neoplasms Vitamin B Complex

Connections (2)

This publication is referenced by other Labnodes entities: