Harlequin ichthyosis: an ultrastructural study.

Fleck RM, Barnadas M, Schulz WW, Roberts LJ, Freeman RG
J Am Acad Dermatol. 1989 21 (5 Pt 1): 999-1006

PMID: 2478600 · DOI:10.1016/s0190-9622(89)70289-9

The clinical, electron microscopic, and freeze-fracture features of the skin of a harlequin fetus are described. Ultrastructural findings included large, concentric lamellar bodies, focal absence of intercellular stratum corneum lipid, and an increase in the size of desmosomes and the number of tight junctions. Although the cause of this genodermatosis is unknown, these features may partially explain the marked thickening of stratum corneum that characterizes this disorder.

MeSH Terms (11)

Adult Female Fetus Freeze Fracturing Humans Ichthyosis Infant, Newborn Male Microscopy, Electron, Scanning Skin Staining and Labeling

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