Selenoprotein P and apolipoprotein E receptor-2 interact at the blood-brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration.

Burk RF, Hill KE, Motley AK, Winfrey VP, Kurokawa S, Mitchell SL, Zhang W
FASEB J. 2014 28 (8): 3579-88

PMID: 24760755 · PMCID: PMC4101661 · DOI:10.1096/fj.14-252874

MeSH Terms (21)

Animals Animals, Congenic Biological Transport Blood-Brain Barrier Brain Capillaries Choroid Plexus Endocytosis Endothelial Cells Female LDL-Receptor Related Proteins Low Density Lipoprotein Receptor-Related Protein-2 Male Mice Mice, Inbred C57BL Mice, Knockout Nerve Degeneration Neurons Pregnancy Selenium Selenoprotein P

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