Repurposing staples for viruses: applying peptide design to RSV prophylaxis.

Katen SP, Dermody TS
J Clin Invest. 2014 124 (5): 1889-91

PMID: 24743141 · PMCID: PMC4001561 · DOI:10.1172/JCI75797

Respiratory syncytial virus (RSV) is responsible for lower respiratory tract infections and annually results in 200,000 deaths worldwide. Despite the burden of RSV-associated disease, treatments and preventative measures are limited. In this issue of JCI, Bird and colleagues describe their work using a peptide stapling technique that allowed synthesis of a stable peptide mimic of a portion of the RSV fusion protein. Pretreatment of cells with the stable peptide effectively blocked virus entry. When introduced into mice prior to RSV exposure, the peptide produced a substantial prophylactic effect. This work provides a new way forward in RSV prevention.

MeSH Terms (8)

Animals Female Nose Diseases Peptides Pneumonia, Viral Respiratory Syncytial Viruses Respiratory Syncytial Virus Infections Viral Fusion Proteins

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