Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependence.

Dhanya RP, Sheffler DJ, Dahl R, Davis M, Lee PS, Yang L, Nickols HH, Cho HP, Smith LH, D'Souza MS, Conn PJ, Der-Avakian A, Markou A, Cosford ND
J Med Chem. 2014 57 (10): 4154-72

PMID: 24735492 · PMCID: PMC4033659 · DOI:10.1021/jm5000563

MeSH Terms (12)

Allosteric Regulation Animals Cocaine-Related Disorders Disease Models, Animal Dose-Response Relationship, Drug Drug Design HEK293 Cells Humans Male Rats Rats, Wistar Receptors, Metabotropic Glutamate

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