Personalized medicine to treat arrhythmias.

Roden DM
Curr Opin Pharmacol. 2014 15: 61-7

PMID: 24721655 · PMCID: PMC3984450 · DOI:10.1016/j.coph.2013.11.013

The efficacy of antiarrhythmic drug therapy is incomplete, with responses ranging from efficacy to no effect to severe adverse effects, including paradoxical drug-induced arrhythmia. Most antiarrhythmic drugs were developed at a time when the mechanisms underlying arrhythmias were not well understood. In the last decade, a range of experimental approaches have advanced our understanding of the molecular and genomic contributors to the generation of an arrhythmia-prone heart, and this information is directly informing targeted therapy with existing drugs or the development of new ones. The development of inexpensive whole genome sequencing holds the promise of identifying patients susceptible to arrhythmias in a presymptomatic phase, and thus implementing preventive therapies.

Copyright © 2013 Elsevier Ltd. All rights reserved.

MeSH Terms (5)

Animals Anti-Arrhythmia Agents Arrhythmias, Cardiac Humans Precision Medicine

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