Glucotoxicity targets hepatic glucokinase in Zucker diabetic fatty rats, a model of type 2 diabetes associated with obesity.

Ueta K, O'Brien TP, McCoy GA, Kim K, Healey EC, Farmer TD, Donahue EP, Condren AB, Printz RL, Shiota M
Am J Physiol Endocrinol Metab. 2014 306 (11): E1225-38

PMID: 24714398 · PMCID: PMC4042096 · DOI:10.1152/ajpendo.00507.2013

MeSH Terms (24)

Animals Body Weight Canagliflozin Diabetes Mellitus, Type 2 Eating Glucagon Glucokinase Glucose Glucose Clamp Technique Glucosides Hyperglycemia Hyperinsulinism Immunohistochemistry Liver Male Obesity Organ Size Oxygen Consumption Rats Rats, Zucker RNA, Messenger Sodium-Glucose Transporter 2 Sodium-Glucose Transporter 2 Inhibitors Thiophenes

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