Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids.

Davies SS, Guo L
Chem Phys Lipids. 2014 181: 1-33

PMID: 24704586 · PMCID: PMC4075969 · DOI:10.1016/j.chemphyslip.2014.03.002

Peroxidation of membranes and lipoproteins converts "inert" phospholipids into a plethora of oxidatively modified phospholipids (oxPL) that can act as signaling molecules. In this review, we will discuss four major classes of oxPL: mildly oxygenated phospholipids, phospholipids with oxidatively truncated acyl chains, phospholipids with cyclized acyl chains, and phospholipids that have been oxidatively N-modified on their headgroups by reactive lipid species. For each class of oxPL we will review the chemical mechanisms of their formation, the evidence for their formation in biological samples, the biological activities and signaling pathways associated with them, and the catabolic pathways for their elimination. We will end by briefly highlighting some of the critical questions that remain about the role of oxPL in physiology and disease.

Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

MeSH Terms (5)

Animals Humans Lipid Peroxidation Phospholipids Signal Transduction

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