Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe.

Gentry PR, Kokubo M, Bridges TM, Cho HP, Smith E, Chase P, Hodder PS, Utley TJ, Rajapakse A, Byers F, Niswender CM, Morrison RD, Daniels JS, Wood MR, Conn PJ, Lindsley CW
ChemMedChem. 2014 9 (8): 1677-82

PMID: 24692176 · PMCID: PMC4116439 · DOI:10.1002/cmdc.201402051

MeSH Terms (11)

Acetophenones Animals Drug Evaluation, Preclinical Half-Life Humans Isoxazoles Molecular Probes Muscarinic Antagonists Protein Binding Rats Receptor, Muscarinic M5

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