Seeing the forest for the trees: kidney oncogenomes in relation to therapeutic outcomes.

Chism DD, Rathmell WK
Clin Cancer Res. 2014 20 (7): 1721-3

PMID: 24634386 · PMCID: PMC4077661 · DOI:10.1158/1078-0432.CCR-14-0056

Renal cell carcinoma is a heterogeneous disease, and tissue investigations provide clues that may predict treatment response. Oncogenomic analysis of five outliers, who achieved a sustained response with rapalogs, implicates alterations of the TSC1 and mTOR genes and reveals insights into the conserved evolution of tumors.

©2014 AACR.

MeSH Terms (5)

Carcinoma, Renal Cell Humans Male Protein Kinase Inhibitors TOR Serine-Threonine Kinases

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