2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity.

Wu SY, Yang X, Gharpure KM, Hatakeyama H, Egli M, McGuire MH, Nagaraja AS, Miyake TM, Rupaimoole R, Pecot CV, Taylor M, Pradeep S, Sierant M, Rodriguez-Aguayo C, Choi HJ, Previs RA, Armaiz-Pena GN, Huang L, Martinez C, Hassell T, Ivan C, Sehgal V, Singhania R, Han HD, Su C, Kim JH, Dalton HJ, Kovvali C, Keyomarsi K, McMillan NA, Overwijk WW, Liu J, Lee JS, Baggerly KA, Lopez-Berestein G, Ram PT, Nawrot B, Sood AK
Nat Commun. 2014 5: 3459

PMID: 24619206 · PMCID: PMC4112501 · DOI:10.1038/ncomms4459

MeSH Terms (11)

Animals Cell Line, Tumor Female Humans Immunohistochemistry Mice Mice, Nude Phosphates RNA, Small Interfering RNA-Induced Silencing Complex Xenograft Model Antitumor Assays

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