Targeted zwitterionic near infrared fluorescent probe for improved imaging of type 2 cannabinoid receptors.

Wu Z, Shao P, Zhang S, Bai M
J Biomed Opt. 2014 19 (3): 36006

PMID: 24604536 · PMCID: PMC4019425 · DOI:10.1117/1.JBO.19.3.036006

Recent studies indicate that the type 2 cannabinoid receptors (CB2R) have become an attractive target for treating a variety of pathologies, including cancers, neurodegenerative diseases, inflammation, pain, osteoporosis, immunological disorders and drug abuse. In addition, it appears that many of these diseases have up-regulated CB2R expression. However, the precise role of CB2R in the regulation of diseases remains unclear. The ability to specifically image CB2R would contribute to develop reliable CB2R-based therapeutic approaches with a better understanding of the mechanism of CB2R action in these diseases. We developed a CB2R-targeted zwitterionic near-infrared (NIR) fluorescent probe, ZW760-mbc94. When compared with a previously reported CB2R probe (NIR760-mbc94) with the same targeting moiety but a charged NIR fluorescent dye, ZW760-mbc94 showed improved binding specificity in vitro and ex vivo. Overall, ZW760-mbc94 appears to have great potential as a CB2R-targeted contrast agent.

MeSH Terms (11)

Animals Bridged-Ring Compounds Cell Line, Tumor Female Fluorescent Dyes Mice Mice, Nude Molecular Probes Optical Imaging Pyrazoles Receptor, Cannabinoid, CB2

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