Transforming growth factor beta in the control of epidermal proliferation.

Barnard JA, Bascom CC, Lyons RM, Sipes NJ, Moses HL
Am J Med Sci. 1988 296 (3): 159-63

PMID: 2459967 · DOI:10.1097/00000441-198809000-00003

Transforming growth factor beta is a polypeptide growth factor with a multiplicity of diverse biologic effects. Increasingly, data support a role for TGF beta in the autocrine regulation of normal epithelial cell growth (Figure 1). Definition of the normal pathways for growth stimulation and inhibition of epithelial cell growth by autocrine peptides like TGF beta and TGF alpha undoubtedly will increase understanding of normal growth and development, embryogenesis, wound repair, and tumorigenesis.

MeSH Terms (7)

Cell Differentiation Cell Division Epidermal Cells ErbB Receptors Humans Keratins Transforming Growth Factors

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