A transient interaction between the phosphate binding loop and switch I contributes to the allosteric network between receptor and nucleotide in Gαi1.

Thaker TM, Sarwar M, Preininger AM, Hamm HE, Iverson TM
J Biol Chem. 2014 289 (16): 11331-11341

PMID: 24596087 · PMCID: PMC4036270 · DOI:10.1074/jbc.M113.539064

MeSH Terms (10)

Allosteric Regulation Amino Acid Substitution Animals Crystallography, X-Ray GTP-Binding Protein alpha Subunits, Gi-Go Guanosine 5'-O-(3-Thiotriphosphate) Guanosine Diphosphate Mutation, Missense Protein Structure, Secondary Rats

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