M5 receptor activation produces opposing physiological outcomes in dopamine neurons depending on the receptor's location.

Foster DJ, Gentry PR, Lizardi-Ortiz JE, Bridges TM, Wood MR, Niswender CM, Sulzer D, Lindsley CW, Xiang Z, Conn PJ
J Neurosci. 2014 34 (9): 3253-62

PMID: 24573284 · PMCID: PMC3935086 · DOI:10.1523/JNEUROSCI.4896-13.2014

MeSH Terms (20)

Animals Animals, Newborn Brain Calcium CHO Cells Cricetulus Dopamine Dopaminergic Neurons Dose-Response Relationship, Drug Indoles In Vitro Techniques Membrane Potentials Mice Mice, Inbred C57BL Mice, Knockout Protein Binding Rats Rats, Sprague-Dawley Receptor, Muscarinic M5 Transfection

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