Exome sequencing implicates an increased burden of rare potassium channel variants in the risk of drug-induced long QT interval syndrome.

Weeke P, Mosley JD, Hanna D, Delaney JT, Shaffer C, Wells QS, Van Driest S, Karnes JH, Ingram C, Guo Y, Shyr Y, Norris K, Kannankeril PJ, Ramirez AH, Smith JD, Mardis ER, Nickerson D, George AL, Roden DM
J Am Coll Cardiol. 2014 63 (14): 1430-7

PMID: 24561134 · PMCID: PMC4018823 · DOI:10.1016/j.jacc.2014.01.031

MeSH Terms (23)

Adult Aged Alleles Case-Control Studies Drug-Related Side Effects and Adverse Reactions Exome Female Genetic Predisposition to Disease Genetic Variation Genotype Humans Incidence KCNQ1 Potassium Channel Long QT Syndrome Male Middle Aged Potassium Channels Potassium Channels, Voltage-Gated Predictive Value of Tests Reference Values Risk Assessment Sequence Analysis, Protein Torsades de Pointes

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