Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-α: impact on gastrointestinal cancers driven by secondary bile acids.

Nagathihalli NS, Beesetty Y, Lee W, Washington MK, Chen X, Lockhart AC, Merchant NB
Cancer Res. 2014 74 (7): 2062-72

PMID: 24520077 · PMCID: PMC3975694 · DOI:10.1158/0008-5472.CAN-13-2329

MeSH Terms (19)

ADAM17 Protein ADAM Proteins Amphiregulin Bile Acids and Salts Cyclin D1 Deoxycholic Acid EGF Family of Proteins ErbB Receptors Gastrointestinal Neoplasms Glycoproteins HCT116 Cells Humans Intercellular Signaling Peptides and Proteins Pancreas Phosphorylation Receptors, G-Protein-Coupled src-Family Kinases STAT3 Transcription Factor Transforming Growth Factor alpha

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