p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells.

Forsyth PA, Krishna N, Lawn S, Valadez JG, Qu X, Fenstermacher DA, Fournier M, Potthast L, Chinnaiyan P, Gibney GT, Zeinieh M, Barker PA, Carter BD, Cooper MK, Kenchappa RS
J Biol Chem. 2014 289 (12): 8067-85

PMID: 24519935 · PMCID: PMC3961639 · DOI:10.1074/jbc.M113.513762

MeSH Terms (12)

Amyloid Precursor Protein Secretases Brain Brain Neoplasms Cell Line, Tumor Cell Proliferation Gene Knockdown Techniques Glioma Humans Mutation Neoplastic Stem Cells Nerve Growth Factors Receptor, Nerve Growth Factor

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