Gray & white matter tissue contrast differentiates Mild Cognitive Impairment converters from non-converters.

Jefferson AL, Gifford KA, Damon S, Chapman GW, Liu D, Sparling J, Dobromyslin V, Salat D, Alzheimer’s Disease Neuroimaging Initiative
Brain Imaging Behav. 2015 9 (2): 141-8

PMID: 24493370 · PMCID: PMC4146750 · DOI:10.1007/s11682-014-9291-2

The clinical relevance of gray/white matter contrast ratio (GWR) in mild cognitive impairment (MCI) remains unknown. This study examined baseline GWR and 3-year follow-up diagnostic status in MCI. Alzheimer's Disease Neuroimaging Initiative MCI participants with baseline 1.5 T MRI and 3-year follow-up clinical data were included. Participants were categorized into two groups based on 3-year follow-up diagnoses: 1) non-converters (n = 69, 75 ± 7, 26 % female), and 2) converters (i.e., dementia at follow-up; n = 69, 75 ± 7, 30 % female) who were matched on baseline age and Mini-Mental State Examination scores. Groups were compared on FreeSurfer generated baseline GWR from structural images in which higher values represent greater tissue contrast. A general linear model, adjusting for APOE-status, scanner type, hippocampal volume, and cortical thickness, revealed that converters evidenced lower GWR values than non-converters (i.e., more degradation in tissue contrast; p = 0.03). Individuals with MCI who convert to dementia have lower baseline GWR values than individuals who remain diagnostically stable over a 3-year period, statistically independent of cortical thickness or hippocampal volume.

MeSH Terms (19)

Aged Atrophy Brain Cognitive Dysfunction Datasets as Topic Dementia Disease Progression Female Follow-Up Studies Gray Matter Humans Image Interpretation, Computer-Assisted Linear Models Magnetic Resonance Imaging Male Neuropsychological Tests Organ Size Software White Matter

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