From ST segments to endothelial pathophysiology: hypercholesterolemia and endothelial superoxide production.

Harrison DG
J Clin Invest. 2014 124 (2): 473-5

PMID: 24487641 · PMCID: PMC3904616 · DOI:10.1172/JCI70336

As a young medical resident, I encountered a patient suffering from spontaneous coronary vasospasm and was puzzled by these dramatic alterations in vasomotion. This encounter piqued my interest in understanding the drivers of vascular reactivity. In a paper published in the JCI, my colleagues and I revealed a role for superoxide production in the vascular dysfunction associated with hypercholesterolemia. Subsequent work by our group and others has unveiled complex associations between ROS generation and vascular disease.

MeSH Terms (14)

Animals Biomedical Research Clinical Trials as Topic Coronary Vasospasm Endothelium, Vascular History, 20th Century History, 21st Century Humans Hypercholesterolemia Inflammation Oxidative Stress Reactive Oxygen Species Superoxides Vascular Diseases

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