Multiscale, converging defects of macro-porosity, microstructure and matrix mineralization impact long bone fragility in NF1.

K├╝hnisch J, Seto J, Lange C, Schrof S, Stumpp S, Kobus K, Grohmann J, Kossler N, Varga P, Osswald M, Emmerich D, Tinschert S, Thielemann F, Duda G, Seifert W, El Khassawna T, Stevenson DA, Elefteriou F, Kornak U, Raum K, Fratzl P, Mundlos S, Kolanczyk M
PLoS One. 2014 9 (1): e86115

PMID: 24465906 · PMCID: PMC3897656 · DOI:10.1371/journal.pone.0086115

MeSH Terms (17)

Animals Biomechanical Phenomena Blood Vessels Bone and Bones Bone Density Bone Matrix Calcification, Physiologic Collagen Diaphyses Homeodomain Proteins Mice Mice, Knockout Neurofibromatosis 1 Neurofibromin 1 Osteocytes Porosity Tibia

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