Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: development of a potent and CNS penetrant [3.1.0]-based lead.

Jones CK, Sheffler DJ, Williams R, Jadhav SB, Felts AS, Morrison RD, Niswender CM, Daniels JS, Conn PJ, Lindsley CW
Bioorg Med Chem Lett. 2014 24 (4): 1067-70

PMID: 24461352 · PMCID: PMC3951249 · DOI:10.1016/j.bmcl.2014.01.013

MeSH Terms (7)

Bridged Bicyclo Compounds Dose-Response Relationship, Drug Glycine Plasma Membrane Transport Proteins Humans Molecular Structure Piperidines Structure-Activity Relationship

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