Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor.

Murayama N, van Beuningen R, Suemizu H, Guillouzo CG, Shibata N, Yajima K, Utoh M, Shimizu M, Chesné C, Nakamura M, Guengerich FP, Houtman R, Yamazaki H
Chem Res Toxicol. 2014 27 (2): 304-308

PMID: 24460184 · PMCID: PMC4020009 · DOI:10.1021/tx4004374

MeSH Terms (14)

Aryl Hydrocarbon Hydroxylases Biotransformation Cell Line Cells, Cultured Constitutive Androstane Receptor Cytochrome P-450 CYP2B6 Cytochrome P-450 CYP3A Hepatocytes Humans Pregnane X Receptor Protein Array Analysis Receptors, Cytoplasmic and Nuclear Receptors, Steroid Thalidomide

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