Bisphosphonates inhibit osteosarcoma-mediated osteolysis via attenuation of tumor expression of MCP-1 and RANKL.

Ohba T, Cole HA, Cates JM, Slosky DA, Haro H, Ando T, Schwartz HS, Schoenecker JG
J Bone Miner Res. 2014 29 (6): 1431-45

PMID: 24443409 · DOI:10.1002/jbmr.2182

MeSH Terms (19)

Animals Bone Resorption Cell Differentiation Cell Line, Tumor Cell Proliferation Chemokine CCL2 Diphosphonates Humans Imidazoles Mice Monocytes Neoplasm Invasiveness Osteoclasts Osteogenesis Osteolysis Osteoprotegerin Osteosarcoma RANK Ligand Zoledronic Acid

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