Chemical modulation of glycerolipid signaling and metabolic pathways.

Scott SA, Mathews TP, Ivanova PT, Lindsley CW, Brown HA
Biochim Biophys Acta. 2014 1841 (8): 1060-84

PMID: 24440821 · PMCID: PMC4069240 · DOI:10.1016/j.bbalip.2014.01.009

Thirty years ago, glycerolipids captured the attention of biochemical researchers as novel cellular signaling entities. We now recognize that these biomolecules occupy signaling nodes critical to a number of physiological and pathological processes. Thus, glycerolipid-metabolizing enzymes present attractive targets for new therapies. A number of fields-ranging from neuroscience and cancer to diabetes and obesity-have elucidated the signaling properties of glycerolipids. The biochemical literature teems with newly emerging small molecule inhibitors capable of manipulating glycerolipid metabolism and signaling. This ever-expanding pool of chemical modulators appears daunting to those interested in exploiting glycerolipid-signaling pathways in their model system of choice. This review distills the current body of literature surrounding glycerolipid metabolism into a more approachable format, facilitating the application of small molecule inhibitors to novel systems. This article is part of a Special Issue entitled Tools to study lipid functions.

Copyright © 2014 Elsevier B.V. All rights reserved.

MeSH Terms (8)

Acyltransferases Glycerol Lipase Lipids Phospholipases Phosphoric Monoester Hydrolases Phosphotransferases Signal Transduction

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