Lens capsule as a model to study type IV collagen.

Cummings CF, Hudson BG
Connect Tissue Res. 2014 55 (1): 8-12

PMID: 24437599 · PMCID: PMC4138812 · DOI:10.3109/03008207.2013.867337

The study of collagen IV has benefited greatly from the seminal work conducted by Arthur Veis and colleagues over three decades ago. Through a series of electron microscopy studies focused on lens basement membrane, an appreciation was gained for the distinct network-forming properties of collagen IV. Veis correctly suggested that network assembly is a phenomenon of the non-collagenous termini of the molecule. This review seeks to document how the field advanced following these seminal conclusions, including recent discoveries regarding the molecular reinforcement of networks that support Veis' conclusions.

MeSH Terms (7)

Animals Basement Membrane Cells Collagen Type IV Humans Lens Capsule, Crystalline Models, Biological

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