Oxicams bind in a novel mode to the cyclooxygenase active site via a two-water-mediated H-bonding Network.

Xu S, Hermanson DJ, Banerjee S, Ghebreselasie K, Clayton GM, Garavito RM, Marnett LJ
J Biol Chem. 2014 289 (10): 6799-6808

PMID: 24425867 · PMCID: PMC3945341 · DOI:10.1074/jbc.M113.517987

MeSH Terms (21)

Amino Acid Substitution Animals Anti-Inflammatory Agents, Non-Steroidal Arginine Binding Sites Catalytic Domain Cyclooxygenase 1 Cyclooxygenase 2 Cyclooxygenase Inhibitors Hydrogen Bonding Leucine Meloxicam Mice Mutation Piroxicam Protein Structure, Secondary Serine Thiazines Thiazoles Tyrosine Water

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