Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.

Gomes AP, Price NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA
Cell. 2013 155 (7): 1624-38

PMID: 24360282 · PMCID: PMC4076149 · DOI:10.1016/j.cell.2013.11.037

MeSH Terms (14)

Aging AMP-Activated Protein Kinases Animals Cell Nucleus Hypoxia-Inducible Factor 1, alpha Subunit Mice Mitochondria Muscle, Skeletal NAD Oxidative Phosphorylation Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Reactive Oxygen Species Sirtuin 1 Transcription Factors

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