Inflammation and mechanical stretch promote aortic stiffening in hypertension through activation of p38 mitogen-activated protein kinase.

Wu J, Thabet SR, Kirabo A, Trott DW, Saleh MA, Xiao L, Madhur MS, Chen W, Harrison DG
Circ Res. 2014 114 (4): 616-25

PMID: 24347665 · PMCID: PMC4186716 · DOI:10.1161/CIRCRESAHA.114.302157

MeSH Terms (24)

Adoptive Transfer Angiotensin II Animals Aortic Diseases CD4 Antigens CD8 Antigens Cells, Cultured Collagen Disease Models, Animal Elastin Fibroblasts Homeodomain Proteins Hypertension Inflammation Interleukin-17 Male Mice Mice, Knockout p38 Mitogen-Activated Protein Kinases Stress, Mechanical T-Lymphocytes Vascular Stiffness Vasculitis Vasoconstrictor Agents

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