The primary function of gp130 signaling in osteoblasts is to maintain bone formation and strength, rather than promote osteoclast formation.

Johnson RW, Brennan HJ, Vrahnas C, Poulton IJ, McGregor NE, Standal T, Walker EC, Koh TT, Nguyen H, Walsh NC, Forwood MR, Martin TJ, Sims NA
J Bone Miner Res. 2014 29 (6): 1492-505

PMID: 24339143 · DOI:10.1002/jbmr.2159

MeSH Terms (27)

Adaptor Proteins, Signal Transducing Animals Bone and Bones Cell Count Cell Lineage Collagen Type I Cytokine Receptor gp130 Female Gene Deletion Gene Knockdown Techniques Glycoproteins Integrases Intercellular Signaling Peptides and Proteins Male Mice, Inbred C57BL Mice, Knockout Models, Biological Organ Size Osteoblasts Osteocalcin Osteoclasts Osteocytes Osteogenesis Reproducibility of Results Signal Transduction Sp7 Transcription Factor Transcription Factors

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