The primary function of gp130 signaling in osteoblasts is to maintain bone formation and strength, rather than promote osteoclast formation.

Johnson RW, Brennan HJ, Vrahnas C, Poulton IJ, McGregor NE, Standal T, Walker EC, Koh TT, Nguyen H, Walsh NC, Forwood MR, Martin TJ, Sims NA
J Bone Miner Res. 2014 29 (6): 1492-505

PMID: 24339143 · DOI:10.1002/jbmr.2159

Interleukin-6 (IL-6) family cytokines act via gp130 in the osteoblast lineage to stimulate the formation of osteoclasts (bone resorbing cells) and the activity of osteoblasts (bone forming cells), and to inhibit expression of the osteocyte protein, sclerostin. We report here that a profound reduction in trabecular bone mass occurs both when gp130 is deleted in the entire osteoblast lineage (Osx1Cre gp130 f/f) and when this deletion is restricted to osteocytes (DMP1Cre gp130 f/f). This was caused not by an alteration in osteoclastogenesis, but by a low level of bone formation specific to the trabecular compartment. In contrast, cortical diameter increased to maintain ultimate bone strength, despite a reduction in collagen type 1 production. We conclude that osteocytic gp130 signaling is required for normal trabecular bone mass and proper cortical bone composition.

© 2014 American Society for Bone and Mineral Research.

MeSH Terms (25)

Animals Bone and Bones Cell Count Cell Lineage Collagen Type I Cytokine Receptor gp130 Female Gene Deletion Gene Knockdown Techniques Glycoproteins Integrases Male Mice, Inbred C57BL Mice, Knockout Models, Biological Organ Size Osteoblasts Osteocalcin Osteoclasts Osteocytes Osteogenesis Reproducibility of Results Signal Transduction Sp7 Transcription Factor Transcription Factors

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