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Response inhibition during perceptual decision making in humans and macaques.

Middlebrooks PG, Schall JD
Atten Percept Psychophys. 2014 76 (2): 353-66

PMID: 24306985 · PMCID: PMC4141461 · DOI:10.3758/s13414-013-0599-6

Response inhibition in stop signal tasks has been explained as the outcome of a race between GO and STOP processes (e.g., Logan, 1981). Response choice in two-alternative perceptual categorization tasks has been explained as the outcome of an accumulation of evidence for the alternative responses. To begin unifying these two powerful investigation frameworks, we obtained data from humans and macaque monkeys performing a stop signal task with responses guided by perceptual categorization and variable degrees of difficulty, ranging from low to high accuracy. Comparable results across species reinforced the validity of this animal model. Response times and errors increased with categorization difficulty. The probability of failing to inhibit responses on stop signal trials increased with stop signal delay, and the response times for failed stop signal trials were shorter than those for trials with no stop signal. Thus, the Logan race model could be applied to estimate the duration of the stopping process. We found that the duration of the STOP process did not vary across a wide range of discrimination accuracies. This is consistent with the functional, and possibly mechanistic, independence of choice and inhibition mechanisms.

MeSH Terms (16)

Adult Animals Attention Choice Behavior Discrimination, Psychological Eye Movements Female Humans Inhibition, Psychological Macaca Male Probability Reaction Time Saccades Species Specificity Task Performance and Analysis

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