Mild footshock stress dissociates substance P from substance K and dynorphin from Met- and Leu-enkephalin.

Bannon MJ, Deutch AY, Tam SY, Zamir N, Eskay RL, Lee JM, Maggio JE, Roth RH
Brain Res. 1986 381 (2): 393-6

PMID: 2428438 · DOI:10.1016/0006-8993(86)90097-1

Mild footshock stress selectively activates ventral tegmental area dopamine neurons innervating the prefrontal cortex. The same stressor rapidly dissociates ventral tegmental substance P from its preprotachykinin-derived co-transmitter substance K, and preproenkephalin B-derived dynorphin B from preproenkephalin A-derived Met-enkephalin-Arg-Gly-Leu and Leu-enkephalin. Mild footshock stress may provide a paradigm for studying both peptidergic modulation of brain dopaminergic neurons and the dynamic regulation of tachykinin and opioid peptide transcription, processing and utilization.

MeSH Terms (13)

Animals Brain Chemistry Enkephalin, Leucine Enkephalin, Methionine Frontal Lobe Male Neurokinin A Neuropeptides Rats Rats, Inbred Strains Stress, Psychological Substance P Tegmentum Mesencephali

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