Pediatric intracerebral hemorrhage score: a simple grading scale for intracerebral hemorrhage in children.

Beslow LA, Ichord RN, Gindville MC, Kleinman JT, Engelmann K, Bastian RA, Licht DJ, Smith SE, Hillis AE, Jordan LC
Stroke. 2014 45 (1): 66-70

PMID: 24281231 · PMCID: PMC3910321 · DOI:10.1161/STROKEAHA.113.003448

BACKGROUND AND PURPOSE - The intracerebral hemorrhage (ICH) score is the most commonly used clinical grading scale for outcome prediction after adult ICH. We created a similar scale in children to inform clinical care and assist in clinical research.

METHODS - Children, full-term newborns to 18 years, with spontaneous ICH were prospectively enrolled from 2007 to 2012 at 3 centers. The pediatric ICH score was created by identifying factors associated with poor outcome. The score's ability to detect moderate disability or worse and severe disability or death was examined with sensitivity, specificity, and area under the receiver operating characteristic curve.

RESULTS - The pediatric ICH score components include ICH volume>2% to 3.99% of total brain volume (TBV): 1 point; ICH volume≥4% TBV: 2 points; acute hydrocephalus: 1 point; herniation: 1 point; and infratentorial location: 1 point. The score ranges from 0 to 5. At 3-month follow-up of 60 children, 10 were severely disabled or dead, 30 had moderate disability, and 20 had good recovery. A pediatric ICH score≥1 predicted moderate disability or worse with a sensitivity of 75% (95% confidence interval [CI], 59% to 87%) and a specificity of 70% (95% CI, 46% to 88%). A pediatric ICH score≥2 predicted severe disability or death with a sensitivity and specificity of 90% (95% CI, 55% to 99%) and 68% (95% CI, 53% to 80%), respectively. The area under the receiver operating characteristic curve for classifying outcome as severe disability or death was 0.88 (95% CI, 0.78-0.97).

CONCLUSIONS - The pediatric ICH score is a simple clinical grading scale that may ultimately be used for risk stratification, clinical care, and research.

MeSH Terms (23)

Adolescent Age Factors Brain Cerebral Hemorrhage Cerebral Ventricles Child Child, Preschool Cohort Studies Disability Evaluation Female Humans Hydrocephalus Infant Infant, Newborn Male Neurosurgical Procedures Predictive Value of Tests Prognosis Prospective Studies Recovery of Function ROC Curve Sex Factors Treatment Outcome

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