Arrestin-3 binds c-Jun N-terminal kinase 1 (JNK1) and JNK2 and facilitates the activation of these ubiquitous JNK isoforms in cells via scaffolding.

Kook S, Zhan X, Kaoud TS, Dalby KN, Gurevich VV, Gurevich EV
J Biol Chem. 2013 288 (52): 37332-42

PMID: 24257757 · PMCID: PMC3873585 · DOI:10.1074/jbc.M113.510412

MeSH Terms (17)

Animals Arrestins Cell Proliferation Cell Survival Chlorocebus aethiops COS Cells Enzyme Activation Isoenzymes MAP Kinase Kinase 7 MAP Kinase Kinase Kinase 5 MAP Kinase Signaling System Mice Mice, Knockout Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinase 9 Phosphorylation Protein Binding

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