Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors.

Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC
Cell. 2013 155 (4): 844-57

PMID: 24209622 · PMCID: PMC4070383 · DOI:10.1016/j.cell.2013.09.057

MeSH Terms (17)

Animals Breast Neoplasms Cell Line, Tumor Cell Proliferation Cell Respiration Cellular Senescence Embryo, Mammalian Gene Knockdown Techniques Genes, Lethal Heterografts Humans Mice Neoplasm Transplantation Phosphotransferases (Alcohol Group Acceptor) Reactive Oxygen Species Signal Transduction Tumor Suppressor Protein p53

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