25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages.

Shibata N, Carlin AF, Spann NJ, Saijo K, Morello CS, McDonald JG, Romanoski CE, Maurya MR, Kaikkonen MU, Lam MT, Crotti A, Reichart D, Fox JN, Quehenberger O, Raetz CR, Sullards MC, Murphy RC, Merrill AH, Brown HA, Dennis EA, Fahy E, Subramaniam S, Cavener DR, Spector DH, Russell DW, Glass CK
J Biol Chem. 2013 288 (50): 35812-23

PMID: 24189069 · PMCID: PMC3861632 · DOI:10.1074/jbc.M113.519637

MeSH Terms (17)

Animals Bone Marrow Cells Cholesterol Esters Gene Expression Profiling Hydroxycholesterols Liver X Receptors Macrophages Mice Mice, Inbred C57BL Muromegalovirus Orphan Nuclear Receptors Oxidative Stress Protein Biosynthesis Signal Transduction Sphingolipids Sterol Regulatory Element Binding Proteins Transcription, Genetic

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