Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: a children's oncology group study.

Borinstein SC, Barkauskas DA, Bernstein M, Goorin A, Gorlick R, Krailo M, Schwartz CL, Wexler LH, Toretsky JA
Pediatr Blood Cancer. 2014 61 (4): 749-52

PMID: 24178953 · PMCID: PMC3946315 · DOI:10.1002/pbc.24778

To investigate the role of insulin-like growth factor-1 (IGF-1), in localized osteosarcoma, serum levels of IGF-1, IGFBP-2, and IGFBP-3 were measured in 224 similarly treated, newly diagnosed patients. We demonstrated that younger patients had lower concentrations of IGF-1 and IGFBP-3 compared to older (P < 0.001) along with lower IGFBP-3:IGF-1 and IGFBP-2:IGF-1 ratios (P < 0.001). IGFBP-2 did not correlate with age (P = 0.16), yet IGFBP-2:IGF-1 ratios were higher in the younger population (P < 0.001). These findings show that older patients have higher concentrations of free IGF-1. None of IGF-1, IGFBP-2, nor IGFBP-3 concentrations were associated with event-free nor overall survival.

© 2013 Wiley Periodicals, Inc.

MeSH Terms (20)

Adolescent Age Factors Antineoplastic Combined Chemotherapy Protocols Biomarkers, Tumor Bone Neoplasms Child Child, Preschool Female Follow-Up Studies Humans Infant Infant, Newborn Insulin-Like Growth Factor Binding Protein 2 Insulin-Like Growth Factor Binding Protein 3 Insulin-Like Growth Factor I Male Osteosarcoma Prognosis Prospective Studies Survival Rate

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