Expression of the c-myc protooncogene in human prostatic carcinoma and benign prostatic hyperplasia.

Fleming WH, Hamel A, MacDonald R, Ramsey E, Pettigrew NM, Johnston B, Dodd JG, Matusik RJ
Cancer Res. 1986 46 (3): 1535-8

PMID: 2417706

We have examined the level of c-myc transcripts in prostate tissue obtained from patients with both benign prostatic hyperplasia and adenocarcinoma of the prostate. A significantly higher level of c-myc transcripts is observed in patients with adenocarcinoma (P less than 0.05). In addition, a subset of patients with adenocarcinoma had levels of c-myc transcripts 2-fold higher than the mean level for this group. These preliminary results indicate that the investigation of c-myc levels as a prognostic indicator in prostatic carcinoma is warranted.

MeSH Terms (13)

Acid Phosphatase Aged Gene Expression Regulation Humans Male Middle Aged Prognosis Prostatic Hyperplasia Prostatic Neoplasms Proto-Oncogene Proteins Proto-Oncogenes RNA, Messenger RNA, Neoplasm

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