Immune responses to pertussis vaccines and disease.

Edwards KM, Berbers GA
J Infect Dis. 2014 209 Suppl 1: S10-5

PMID: 24158958 · DOI:10.1093/infdis/jit560

In this article we discuss the following: (1) acellular vaccines are immunogenic, but responses vary by vaccine; (2) pertussis antibody levels rapidly wane but promptly increase after vaccination; (3) whole-cell vaccines vary in immunogenicity and efficacy; (4) whole-cell vaccines and naturally occurring pertussis generate predominantly T-helper 1 (Th1) responses, whereas acellular vaccines generate mixed Th1/Th2 responses; (5) active transplacental transport of pertussis antibody is documented; (6) neonatal immunization with diphtheria toxoid, tetanus toxoid, and acellular pertussis vaccine has been associated with some suppression of pertussis antibody, but suppression has been seen less often with acellular vaccines; (7) memory B cells persist in both acellular vaccine- and whole cell vaccine-primed children; and (8) in acellular vaccine-primed children, T-cell responses remain elevated and do not increase with vaccine boosters, whereas in whole-cell vaccine-primed children, these responses can be increased by vaccine boosting and natural exposure. Despite these findings, challenges remain in understanding the immune response to pertussis vaccines.

MeSH Terms (9)

Antibodies, Bacterial B-Lymphocytes Humans Immunologic Memory Pertussis Vaccine T-Lymphocyte Subsets Vaccines, Acellular Vaccines, Inactivated Whooping Cough

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