The roles of TGFβ in the tumour microenvironment.

Pickup M, Novitskiy S, Moses HL
Nat Rev Cancer. 2013 13 (11): 788-99

PMID: 24132110 · PMCID: PMC4025940 · DOI:10.1038/nrc3603

The influence of the microenvironment on tumour progression is becoming clearer. In this Review we address the role of an essential signalling pathway, that of transforming growth factor-β, in the regulation of components of the tumour microenvironment and how this contributes to tumour progression.

MeSH Terms (16)

Adaptive Immunity Animals Cell Movement Disease Progression Epigenesis, Genetic Fibroblasts Gene Expression Regulation, Neoplastic Humans Immunity, Innate Mice Neoplasms Phenotype Signal Transduction Stromal Cells Transforming Growth Factor beta Tumor Microenvironment

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