Detection and characterization of 1,2-dibromoethane-derived DNA crosslinks formed with O(6) -alkylguanine-DNA alkyltransferase.

Chowdhury G, Cho SH, Pegg AE, Guengerich FP
Angew Chem Int Ed Engl. 2013 52 (49): 12879-82

PMID: 24130045 · PMCID: PMC4048925 · DOI:10.1002/anie.201307580

A combination of chemical modifications and LC-tandem MS was used for the structure elucidation of various ethylene crosslinks of DNA with O(6) -alkylguanine-DNA alkyltransferase (AGT, see picture). The elucidation of the chemical structures of such DNA-protein crosslinks is necessary to understand mechanisms of mutagenesis.

Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

MeSH Terms (8)

Animals DNA DNA Adducts DNA Damage Humans Hydrogenation Mutation O(6)-Methylguanine-DNA Methyltransferase

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