No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population.

Dumitrescu L, Carty CL, Franceschini N, Hindorff LA, Cole SA, Bůžková P, Schumacher FR, Eaton CB, Goodloe RJ, Duggan DJ, Haessler J, Cochran B, Henderson BE, Cheng I, Johnson KC, Carlson CS, Love SA, Brown-Gentry K, Nato AQ, Quibrera M, Shohet RV, Ambite JL, Wilkens LR, Le Marchand L, Haiman CA, Buyske S, Kooperberg C, North KE, Fornage M, Crawford DC
Hum Genet. 2013 132 (12): 1427-31

PMID: 24100633 · PMCID: PMC3895337 · DOI:10.1007/s00439-013-1375-3

Genome-wide association studies (GWAS) have identified many variants that influence high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and/or triglycerides. However, environmental modifiers, such as smoking, of these known genotype-phenotype associations are just recently emerging in the literature. We have tested for interactions between smoking and 49 GWAS-identified variants in over 41,000 racially/ethnically diverse samples with lipid levels from the Population Architecture Using Genomics and Epidemiology (PAGE) study. Despite their biological plausibility, we were unable to detect significant SNP × smoking interactions.

MeSH Terms (17)

Cholesterol, HDL Cholesterol, LDL Cohort Studies Ethnic Groups Female Gene-Environment Interaction Gene Frequency Genetics, Population Genome-Wide Association Study Humans Lipid Metabolism Male Polymorphism, Single Nucleotide Prevalence Smoking Triglycerides Young Adult

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